The Missouri (MO) state sales tax rate is currently 4.225%, ranking 22nd-highest in the U.S. Depending on local municipalities, the total tax rate can be as high as 10.1%. The average local rate is 2.8%. The average combined tax rate is 7.03%, ranking 22nd in the US.

Use tax is imposed on the storage, use or consumption of tangible personal property in this state. If an out-of -state seller does not collect use tax from the purchaser, the purchaser is responsible for remitting the use tax to Missouri. A purchaser is required to file a use tax return if the cumulative purchases subject to use tax exceed two thousand dollars in a calendar year.

In some of the cities, local taxes apply to both intra-state and inter-state transactions.

In Missouri, food or food products for home consumption, seeds and plants for use in gardens to produce food for personal consumption and food items refrigerated or at room temperature are taxed at a reduced rate of 1.225% (one percent plus constitutional taxes of .225%). Sales of prescription drugs, insulin, prosthetic devices, and orthopedic devices are exempt from tax.

Missouri has two annual tax holidays: Back to School Sales Tax Holiday (8/3/2018 - 8/5/2018) - certain back-to-school purchases, such as clothing, school supplies, computers, and other items as defined by the statute, are exempt from sales tax for this time period only. Show-Me Green Sales Tax Holiday (4/19 - 4/25 each year) - sales of qualifying Energy Star certified new appliances will be exempt from state sales tax.